منابع مشابه
Three-dimensional structure of a recombinant gap junction membrane channel.
Gap junction membrane channels mediate electrical and metabolic coupling between adjacent cells. The structure of a recombinant cardiac gap junction channel was determined by electron crystallography at resolutions of 7.5 angstroms in the membrane plane and 21 angstroms in the vertical direction. The dodecameric channel was formed by the end-to-end docking of two hexamers, each of which display...
متن کاملFunctional analysis of human cardiac gap junction channel mutants.
The connexins form a family of membrane spanning proteins that assemble into gap junction channels. The biophysical properties of these channels are dependent upon the constituent connexin isoform. To begin identifying the molecular basis for gap junction channel behavior in the human heart, a tissue that expresses connexin43, we used site-directed mutagenesis to generate mutant cDNAs of human ...
متن کاملThe Gap Junction Communication Channel
Communication plays an important role in the rapid Connexin Structure progress of modern society. We live in an age when Gap junctions exhibit a hierarchy of assembly. The prininformation is transmitted through many different pathcipal structural component, the membrane protein conways and in many different forms to influence our daily nexin, is organized into the basic unit of structure, the d...
متن کاملOn gap junction structure
We have studied the stain distribution within rat liver gap junctions for specimens prepared by thin sectioning and negative staining. Pools of stain molecules exist in two specific locations with respect to the distinctive morphological units (connexons) of the junction. One pool of stain surrounds the connexons and is restricted to the extracellular space in the gap between the adjacent plasm...
متن کاملThree-dimensional structure of a human connexin26 gap junction channel reveals a plug in the vestibule.
Connexin molecules form intercellular membrane channels facilitating electronic coupling and the passage of small molecules between adjoining cells. Connexin26 (Cx26) is the second smallest member of the gap junction protein family, and mutations in Cx26 cause certain hereditary human diseases such as skin disorders and hearing loss. Here, we report the electron crystallographic structure of a ...
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ژورنال
عنوان ژورنال: Seibutsu Butsuri
سال: 2010
ISSN: 0582-4052,1347-4219
DOI: 10.2142/biophys.50.190